Jobs in the United States

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Added 2 mins ago
R
Senior Engineer, Backend, Bill Pay
Ramp
New York City, NY
- $204,000 to $280,000 USD / year
The problems are high-stakes, data-dense, and unforgiving.
Added 2 mins ago
Senior/Staff Forward Deployed Engineer - Resilient Edge & Tactical Networking
webAI
Remote, United States
At webAI we firmly believe that the future of AI lies in distributed processing at the edge, bringing computation closer to the source of data generation. Our mission is to build a future…
Added 2 mins ago
Senior/Staff Software Engineer - Distributed Systems
webAI
Austin, TX
At webAI we firmly believe that the future of AI lies in distributed processing at the edge, bringing computation closer to the source of data generation. Our mission is to build a future…
Added 5 mins ago
Business Order Engineer
CTC
Baxter, MN
The Business Order Engineer is responsible for the full lifecycle of business service orders, from pre-sales validation through post-installation support. Key responsibilities include…
Added 6 mins ago
Java Kafka Streaming Lead Software Engineer
JPMC page
Columbus, OH
Experience building and operating high-volume data processing pipelines using Apache Spark (Spark SQL, Structured Streaming) and/or Apache Flink (DataStream/Table API) in production.
Added 8 mins ago
Cloud Computing Engineer I
The University of Central Florida Board of Trustees
Orlando, FL
…key functional areas such as research administration systems, data and analytics, application development, systems integration, and customer…
Added 9 mins ago
Audio DSP & Tuning Engineer
Rivian
Palo Alto, CA
…electric vehicle lineup. We are seeking an Audio DSP & Tuning Engineer to own and advance our core audio DSP architectures, signal processing algorithms, and cabin acoustic tuning. Working…
Added 11 mins ago
CP
Software Engineer, AI Systems and GPU Workloads - Information Technology Services
Cal Poly
CA
- $87,408 to $127,332 USD / year
…computing, including artificial intelligence, cybersecurity, data science, advanced wireless networks, robotics and automation, semiconductors, embedded systems, and other emerging…
Added 13 mins ago
Senior Digital Buildings Engineer
Facility Performance Consulting Limited
San Francisco Bay Area
The Senior Digital Buildings Engineer contributes to integrating various BMS, IoT devices, and facility management systems into a cloud platform, working across different vendors and…
Added 13 mins ago
Electrical Engineer V
CDI Engineering Services
Houston, TX
Review electrical equipment development: packaged equipment specifications and data sheets, Request for Qualifications (RFQ's), technical bid summaries, and provide purchase recommendations.
Added 14 mins ago
PE Package Engineering
Rambus
San Jose, CA
Employees are encouraged to work onsite an average of at least three days per week, with up to two days of remote work
Added 16 mins ago
Exploration Geologist I
GOLDEN QUEEN MINING COMPANY LLC
Mojave, CA
…the Americas. With two cornerstone assets - the San Bartolomé processing facility in Potosí, Bolivia, and the Soledad Mountain Project in Kern County, California - we are expanding our…
Added 17 mins ago
Enterprise - Senior DataOps Engineer - JSON, SQL, Python
Erias Ventures, LLC
Ft. Meade, MD
Must have a current/active DoD 8140 / 8570 IAT Level II compliance certifications
Added 17 mins ago
Software Engineer, Applied ML
Apple
Cupertino, CA
Data processing: Skilled in working with large, noisy datasets.
Added 21 mins ago
Engineer
Actalent
Minnetonka, MN
Job Title: Process Development Engineer (Contractor)Job DescriptionThis contract Process Development Engineer role focuses on developing, validating, and improving manufacturing processes…
Added 21 mins ago
Engineer, Process Development
Actalent
Minnetonka, MN
Job Title: Process Development Engineer (Contractor)Job DescriptionThis contract Process Development Engineer role focuses on developing, validating, and improving manufacturing processes…
Added 21 mins ago
Senior Embedded Systems Software Engineer
Neon Aerospace
Irvine, CA
Neon Aero is seeking a Senior Embedded Systems Software Engineer with strong systems intuition and a passion for building robust, safety-critical control software to work onsite in Irvine,…
Added 21 mins ago
Vice President, Senior Director / Director, R&D
The Fynder Group
Chicago, IL
…connections between genotypes and key phenotypes of Fusarium to engineer improved strains with enhanced yield, stability, and functional…
Added 22 mins ago
Human Resource Manager
Real Time Consulting, LLC
Phoenix, AZ
PHR Certification Required (active)
Added 22 mins ago
Software Development Engineer - Network Observability, Leo Networking Software
Amazon Kuiper Manufacturing Enterprises LLC
Redmond, WA
As a software engineer on this team, you will build high-scale systems that transform telemetry, network events, traces, and operational signals into actionable visibility. You will work…
Added 22 mins ago
ADAS Vehicle Test Engineer
ALTEN Technology USA
Chelsea, MI · Troy, MI
The test engineer will assist with driving vehicles, collecting and processing data, and compiling results
Added 28 mins ago
VH
Senior Data Engineer
Vatica Health
Remote, United States
- $115,000 to $125,000 USD / year
As a Senior Data Engineer, you will design, build, and operate the data pipelines and APIs that support our data-driven and AI-enabled products. You will own how data moves from ingestion…
Added 28 mins ago
Vice President, AI / Machine Learning Software Engineer
BNY
New York, NY · NY
In this role you will Build robust batch/streaming data pipelines and transformations that ensure high‑quality, governed data flows into AI and analytics platforms. Implement data modeling,…
Added 30 mins ago
Data Engineer, Senior
Booz Allen Hamilton_United States
Huntsville, AL
…intelligence means that there’s more structured and unstructured data available today than ever before. As a data engineer, you know that organizing data can yield pivotal insights when…
Added 31 mins ago
Data Engineer IV
Grainger Businesses
LAKE FOREST, IL
As the senior technical engineer, design and implement highly efficient, reusable, and scalable data processing systems and pipelines across the tech stack, including Kubernetes,…

A-Alpha Bio

Scientist II, Applied Machine Learning

Seattle, WA, United States

$139,000 to $175,000 USD / year

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Job details

Pay: $139,000 to $175,000 USD / year
Work location: Candidates must reside in the United States
Posting language: English
Posted: Nov 10, 2026

Original job description

A-Alpha Bio is an early-stage, rapidly growing biotechnology platform company headquartered in Seattle, WA. We are focused on building the foundational data layer for AI-driven protein engineering. We provide biopharma companies and model builders with access to ground truth experimental datasets, including affinity and structure, for training, benchmarking and validating AI protein models. In parallel, we apply our data and models directly with select partners to engineer next-generation dual-specific and molecular glue therapeutics, and to discover and optimize differentiated biologics.

A-Alpha Bio is headquartered in Seattle, WA, but remote applicants are welcome to apply. Candidates must reside in the United States.

Starting Salary Range: $139,000 - $175,000 annually

Exemption Status: Exempt

Location Expectations: Remote-Eligible (expected travel to Seattle HQ once per quarter)

Reporting To: Director, Applied Machine Learning

Role Description

A-Alpha Bio is seeking a Scientist II to join our Applied Machine Learning team in turning large-scale protein interaction data into insights and models that advance antibody and protein engineering. In this role, you’ll lead computational work for both internal research and external collaborations, from defining scientific questions and analysis plans to developing models and communicating results. Working with AlphaSeq datasets, you’ll connect experimental measurements with protein sequence and structural information to understand binding, evaluate computational design methods, and guide future experiments. Success in this role will depend on ability to state assumptions, clearly define goals and objectives, and explain your procedures thoughtfully.

Key Responsibilities

Lead scientific analyses:Define and execute analysis plans for large-scale protein interaction datasets (often 1M PPIs), including evaluating binding affinity, specificity, and the performance of antibody and protein design methods.
Develop and evaluate ML models: Build, train, and apply models using experimental measurements, protein sequences, and structural information. Design rigorous benchmarks and assess model performance, uncertainty, and generalization.
Connect computation with experiments: Collaborate with experimental scientists to shape study designs, interpret results, investigate unexpected findings, and recommend follow-up experiments.
Deliver results to external partners: Serve as the computational lead for assigned projects, producing clear presentations, reports, and well-documented datasets for both internal teams and external collaborators. Many projects may have open-source elements, requiring a strong eye for detail and narrative.
Build reusable methods: Translate project-specific work into reliable analytical tools and workflows. Contribute maintainable Python code, review contributions, and document methods so others can use them.
Advance our scientific capabilities: Identify and develop new computational approaches that increase the value of AlphaSeq data for protein engineering.

Qualifications & Experience

Required

PhD in a relevant field with 2+ years of experience working on large-scale data analysis using biological sequence or structure data; or a bachelor’s degree with 10+ years of relevant experience, including 5+ years working onlarge-scale data analysis using biological sequence or structure data; or an equivalent education and experience.
Demonstrated expertise in Python for scientific computing, data analysis, visualization, and ML model development.
Experience analyzing large experimental datasets and making scientifically defensible decisions about data quality, statistical methods, and interpretation.
Strong understanding of model evaluation, including appropriate baselines, data leakage, and the limits of conclusions drawn from a benchmark.
Ability to translate an open-ended scientific question into an executable plan and deliver reproducible results with limited supervision.
Clear communication skills, including the ability to explain methods, findings, and limitations to computational and experimental audiences.
Experience contributing to a shared codebase through version control, code review, and documentation.

Preferred

Experience with antibody or protein engineering, particularly the relationship between sequence, structure, and binding.
Familiarity with the structural modeling of protein complexes and evaluation of structure prediction or generative design methods.
Use of modern ML frameworks such as PyTorch, TensorFlow, or Hugging Face.
Experience processing and analyzing next-generation sequencing data, (Illumina, Oxford Nanopore, etc.).
Experience developing analytical tools or workflows used by other scientists.

In 2018, A-Alpha Bio spun out of the University of Washington’s Institute for Protein Design and Center for Synthetic Biology – both communities filled with brilliant and highly entrepreneurial scientists. Since the company’s inception, we have built and scaled AlphaSeq, our high-throughput platform for quantitatively measuring protein-protein interactions at unprecedented scale. What began as a technology for generating large, standardized affinity datasets has grown into a broader data engine for AI-driven protein engineering. New members of the team should expect a fast-paced, highly dynamic, and interdisciplinary work environment. We are building a diverse, meritocratic, and supportive team that shares our values of speaking the truth, shooting for the moon, taking the reins, playing for the team, and improving the world.

A-Alpha Bio is headquartered in a custom designed lab and office space in downtown Seattle’s Belltown neighborhood. We are fortunate to be situated in a region that is renowned for its premier outdoor activities, including hiking, biking, climbing, skiing, kayaking, sailing, and more. At A-Alpha, you’ll find many who love the outdoors, but also gamers, amateur chefs, explorers, sports fans, bakers, crafters, photographers, brewers, jetsetters, animal lovers, and artists. Whatever your passions, you belong at A-Alpha Bio!

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Jobs in the United States