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4D Molecular Therapeutics

Senior Clinical Trial Manager (Contract)

Remote, United States

$84 to $98 USD / hour

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Job details

Pay: $84 to $98 USD / hour
Experience: 7+ years of clinical research experience within the biotech or a similar industry
Posting language: English
Posted: Nov 9, 2026

Original job description

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future.

4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF biologics (aflibercept and anti-VEGF-C) with a single intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration and the second indication is diabetic macular edema, which are both in Phase 3 development. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery.

We are taking genetic medicine to new heights and into new disease areas to overcome challenges not addressed by existing medicines. This incredible challenge drives our relentless and talented team. Our people are the essence of our inspiring, innovative and collaborative environment that encourages individual contributions and provides opportunities for career development. We seek the best in the industry who identify with our mission and our bold and innovative results-driven approach. Our Core Values drive the way we work together:

Dare to Cure
Break Boundaries
Beyond Yourself
Prepare & Execute Relentlessly

Join us in creating the future of genetic medicine.

GENERAL SUMMARY:

4DMT is seeking an experienced and motivated Senior Clinical Trial Manager (Contract) to support the Company’s clinical trial activities. This position reports to the Associate Director, Clinical Operations within the retina program and is responsible for overseeing and managing the day-to-day operations of multiple Phase 1–3 clinical trials, including trial start-up, conduct, and close-out activities.

MAJOR DUTIES & RESPONSIBILITIES:

Manage protocol execution, including oversight of the CRO, other study service providers, and consultants involved in a clinical trial
Support establishment of study milestones and ensure accurate tracking and reporting of study metrics and timelines to leadership
Ensure clinical trials are managed and executed in accordance with ICH GCP, regulations, the protocol, and company-specific SOPs
Assist in the preparation and review of clinical trial documentation, such as protocols, informed consent forms, pharmacy and laboratory manuals, clinical monitoring plans, project plans, case report forms, vendor management plans, clinical study reports, and other study-level documents
Develop internal tracking and reporting tools to report study status to leadership and facilitate internal project team meetings
Support the management of the Trial Master File (TMF) to ensure compliance/inspection readiness
Participate in and coordinate the resolution of audit findings and ensure that clinical trial documentation, including central clinical files, remains audit-ready
Identify, mitigate, and manage risks, including timely issue review, escalation, and management to support trend analysis and risk prevention
Support the selection and study-specific training of CRO study staff, monitors, investigational sites, and service providers under the AD/Director of Clinical Operations
Facilitate study start-up with CROs and clinical sites as necessary, including working closely with the CRO to complete template clinical documents, such as source document worksheets, CRF specifications and development, clinical site agreements, and other study documentation
Assist data management personnel with activities associated with database lock and clinical study data analyses, and provide study-specific input to the preparation of clinical study reports as directed
Ensure timely response to queries and monitoring discrepancies
Aid in the planning and execution of investigator meetings
Present during cross-functional study execution team (SET) meetings in support of study deliverables
May conduct clinical site, CRO, and/or vendor monitoring visits and co-monitoring visits with CRO staff and/or compliance personnel, including pre-study qualification visits, site initiation visits, eligibility review visits, routine study visits, trial master file review visits, and vendor qualification or selection visits
Oversee outsourced monitoring by reviewing monitoring reports to ensure quality and resolution of site-related issues
Ensure tracking and review of protocol deviations and assess their impact on study data
Provide oversight of clinical supply forecasting, including study drug and other supplies
May manage and/or oversee the work of junior Clinical Operations staff
May support development and review of Clinical SOPs and other department initiatives
Travel as needed to sites, conferences, and industry meetings

QUALIFICATIONS:

Education:

B.A./B.S. degree

Experience:

7+ years of clinical research experience within the biotech or a similar industry
Experience developing trial plans, including creative strategies for site monitoring, risk mitigation, trial budgets, site selection, and clinical supplies management

Other Qualifications/Skills:

(non-technical and technical skills)

Knowledge of GCP, ICH guidelines, and regulatory requirements for clinical trial management; strong clinical study management skills
Understanding of, and experience with, the regulatory framework applicable to interactions with HCPs, payers, advocacy groups, and other business partners
Proven leadership skills to direct protocol execution and ensure timeline, budget, and quality metrics are met
Excellent communication skills to effectively disseminate information to the project team and outside parties
Extensive clinical research knowledge and cross-functional understanding of clinical trial methodology
Excellent organizational, conflict resolution, prioritization, and negotiation skills
Proven ability in creative problem-solving and exercising sound judgment
Team-oriented, with the ability to collaborate effectively with the study team, cross-functional team members, and external partners
Ability to handle a high volume of highly complex tasks within a given timeline
Ability to develop therapeutic area knowledge and expertise through internal training and external conference attendance
Proficient computer skills, specifically with Microsoft Office Suite, including Word, Excel, PowerPoint, and Outlook
Working knowledge of MS Project for developing and updating clinical study timelines

Travel: 20%

Physical Requirements and Working Conditions:

Physical Activity - Repetitive motions: Making substantial movements (motions) of the wrists, hands, and/or fingers. Fingering: Picking, pinching, typing or otherwise working, primarily with fingers rather than with whole hand or arm as in handling. Talking: Expressing or exchanging ideas by means of the spoken word.
Physical Requirements - Sedentary work: Exerting up to 10 pounds of force occasionally and/or a negligible amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects, including the human body. Sedentary work involves sitting most of the time. Jobs are sedentary if walking and standing are required only occasionally and all other sedentary criteria are met.
Working Conditions - The worker is not substantially exposed to adverse environmental conditions (as in typical office or administrative work).

Hourly compensation range: $84.00 - 98.00

Please note that the hourly compensation range and actual hourly rate offered to the final candidate depend on various factors, including the candidate’s geographical location, relevant work experience, skills, and years of experience.

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

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